Intensive Care
This is a list of conditions we currently have research studies for. Click to reveal more.
Genetics in critically-ill patients
GenOMICC Study
What is the study about?
Infectious diseases and severe injuries affect millions of people around the world every year. Most cases are mild, but some people become very unwell. Our genes (or DNA) determine how vulnerable we are to critical illness. If we could find the genes that cause some people to be more vulnerable, we may be able to develop better treatments for patients in the future.
Who can take part?
People with severe illness (such as Covid-19, influenza, sepsis and other causes of critical illness) admitted to intensive care will be approached if eligible to take part.
Find out more
Visit the study website [external]
Lung infections
REMAP-CAP
What is the study about?
COVID-19, flu, and pneumonia (lung infection) are all important current health problems. Current treatments for these are based on previous research used in international guidelines that help doctors to choose the best care. As new treatments become available more research is needed to see whether there are better and more effective treatments. The aim of this study is to investigate which treatments are best for patients admitted to hospital with COVID-19, flu, or pneumonia.
Who can take part?
Patients who have been admitted to hospital or to the Intensive Care Unit, who have or are suspected to have COVID-19, flu or pneumonia. Only patients who meet the study criteria and are considered suitable by their treating doctor will be included. The treatments available are dependent on the severity of the condition and eligibility criteria.
Find out more
Visit the study website [external]
AWAKE Prone
What is this study about?
Respiratory failure can be caused by chest infection. This means that patients need extra oxygen to keep the oxygen levels in their blood at a safe level. Despite the treatment commenced for respiratory failure we know that some patients with respiratory failure will unfortunately get worse and may need to go on a ventilator (breathing machine) in an intensive care unit. The study is aiming to find out if lying on your front (awake prone positioning) or standard care (sitting up in bed) reduces the chance that someone will go on a ventilator.
Who can take part?
Patients admitted to Critical Care with respiratory failure receiving moderate to high amount of oxygen not due to COVID-19 infection.
What is involved?
If you take part, which of these two groups you are in will be decided by chance.
In Awake - Prone position we will ask that you lie on your tummy for at least 8 hours each day for a maximum of five days.
If you are in the standard care group, you will continue to receive standard NHS care. This means that you will normally sit upright in bed.
After leaving hospital, we will ask you to complete a questionnaire about your recovery at 2- and 6-month time-points.
Tell me more
Visit the study website.
How do I take part?
For enquiries, please contact the Critical Care Research Team via email.
Email: wuth.ituresearch@nhs.net
RELEASE Study
What is the study about?
The RELEASE trial is looking to see if Airway Pressure Release Ventilation (APRV) which is a way of using the breathing machine helps patients with diseased lungs to heal faster and spend less time on a ventilator compared to the usual way breathing support is given in critical care.
Who can take part?
Patients admitted to a CCU in the UK who are:
• Aged 18 years or more
• Receiving support from a breathing machine
• Have moderate to severely low oxygen levels
• Are expected by the critical care team to stay on a breathing machine for more than two days
Relatives will be approached by medical team as patient is not able to decide for themself.
What is involved?
After leaving hospital, we will also ask you to complete a questionnaire about your recovery at 2- and 6-month time-points.
Tell me more
Please visit the trial website [external] for more information.
PROTECT Airways
What is the study about?
A research study to find out if an alternative airway system is better than standard care for patients connected to a breathing machine
Who can take part?
Patients admitted to a CCU in the UK who are:
• Aged 18 years or more
• Need for invasive mechanical ventilation
• Are expected by the critical care team to remain ventilated for at least 24 hours
Relatives will be approached by medical team as patient is not able to decide for themself.
What is involved?
If you take part, you will be randomised by chance in two groups:
In PROTECT AIRWAYS – alternative airway system, a type of tube that connects critically ill patients to a breathing machine, will be used for intubation.
If you are in the standard care group, you will continue to receive standard NHS tube for intubation.
After leaving hospital, we will also ask you to complete a questionnaire about your recovery at 2- and 6-month time-points.
Tell me more
Visit the study website [external].
How do I take part?
For enquiries, please contact the Critical Care Research Team via email.
Email: wuth.ituresearch@nhs.net