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Wirral University Hospital NHS Foundation Trust

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Current Research

Please see the menus below for information about our current research.

Anaesthetic Research

Study Title - PQIP – Improving perioperative care through the use of quality data – Patient study of the perioperative Quality Improvement Programme

Principal Investigator: Dr Kathryn Brodbelt

Research Nurses:  Reni Jacob & Cathy Jones

 

Study Title – ALLEGRO – A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

Principal Investigator: Dr Heather Black

Research Nurses:  Reni Jacob & Cathy Jones

Cancer Research

Study Title - ADD-ASPIRIN - A phase III double-blind placebo-controlled randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours

Principal Investigator: Mr Liviu Titu (Colorectal)

Sub Investigators: Mr Nigel Parr (Prostate) and Mr Raman Vinayagam (Breast)

Research Nurse: Liz Bailey

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Study TitleATLANTA – Adjuvant treatments to the local tumour for metastatic prostate cancer: Assessment of novel treatment algorithms

Principal Investigator:  Mr Manal Kumar

Research Nurse: Anne Reddington

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Study TitleBladderpath – Image directed redesign of bladder cancer treatment pathways

Principal Investigator:  Dr Thiagarajan Nambi Rajan

Research Nurse: Jessie Huang

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Study TitleBreast Cancer in Men - A national population-based case-control study of the genetic, environment and behavioural causes of breast cancer in men.

Principal Investigator: Mr Raman Vinayagram

Research Nurse: Liz Bailey   

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Study Title - EMERALD - A window of opportunity study to assess the biological effect of enobosarm in oestrogen receptor positive, androgen receptor positive early breast cancer

Principal Investigator: Mr Raman Vinayagram

Research Nurse: Liz Bailey

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Study Title - LORIS - A Phase III Trial of Surgery versus Active Monitoring for Low Risk Ductal Carcinoma in Situ (DCIS)

Principal Investigator: Mr Raman Vinayagram

Research Nurse: Liz Bailey

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Study TitlePEARL – A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer

Principal Investigator: Mr Raman Vinayagram

Research Nurse: Liz Bailey

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Study Title - POSNOC: Positive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes

Principal Investigator: Mr Raman Vinayagram

Research Nurse: Liz Bailey

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Study Title - TIP - Thrombin Inhibition Preoperatively in Early Breast Cancer

Principal Investigator: Mr Raman Vinayagram

Research Nurse: Liz Bailey

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Study Title - UK Genetic Prostate Cancer Study (UKGPCS)

Principal Investigator: Dr Nigel Parr

Research Nurse: TBC

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Critical Care Research

Study Title - The A-STOP Study - Antifungal stewardship opportunities with rapid tests for fungal infection in critically ill patients  

Principal Investigator: Dr Paul Jeanrenaud

Research Nurses: Reni Jacob & Cathy Jones

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Study TitlePOETICS 2 - Prospective study on over eighty year old Intensive Care patients.

Principal Investigator: Reni Jacob

Research Nurses: Reni Jacob & Cathy Jones

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Dermatology Research

BADBIR -British Association of Dermatologists Biologic Interventions Register

Principal Investigator:  Dr W Farrar

 

Gastroenterology Research

 

Study Title – Records keeping in IBD

Principal Investigator:  Dr Paul Flanagan

Research Nurse:  Liz Bailey

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Haematology Research

Study Title - AML L1 - Leukaemia Lymphoma Research and NCRI Working Group Programme 

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang

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Study Title - AML 18 - A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome

Principal Investigator:   Dr Ranjit Dasgupta

Research Nurse: Jessie Huang

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Study Title - AML 19 - A national cancer research institute acute myeloid leukaemia (AML) working group pilot trial to establish the feasibility of combining tyrosine kinase inhibitor, ponatinib with chemotherapy in patients with AMLwith a flt3 mutation.

Principal Investigator:   Dr Ranjit Dsagupta

Research Nurse: Jessie Huang

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Study Title - MAPLE- Molecular profiling for lymphoma

Principal Investigator:   Dr Barbara Hammer

Research Nurse: Jessie Huang

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Study Title - MCL Biobank - Establishing a Biobank and Database as a National Resource for Characterising Indolent and Aggressive forms of Mantle Cell Lymphoma, an Observational Study.

Principal Investigator:   Dr Barbara Hammer

Research Nurse: Jessie Huang

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Study Title - MEASURES - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms.

Principal Investigator:   Dr Elizabeth Jones

Research Nurse: Jessie Huang

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Study Title – National cohort study of late effects of Hodgkin lymphoma treatment

Principal Investigator:   Dr Barbara Hammer

Research Nurse: Jessie Huang

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Neonatal Research

BABY OSCAR - Outcome After Selective Early Treatment for Closure of Patent Ductus Arteriosus in Preterm Babies

Principal Investigator: Dr Anand Kamalanthan

Research Nurses:  Sharon Hughes and Lucy Lewis

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OPTI-PREM – Optimising Neonatal Service provision for preterm babies born between 27 and 31 weeks of gestation in England, using national data, qualitative research and economic analysis    

Principal Investigator: N/A 

Research Nurses: Lucy Lewis and Sharon Hughes

Orthopaedic Research

Study Title - Achilles Tendinopathy Management (ATM) - A multi-centre placebo controlled randomised controlled trial comparing Platelet Rich Plasma (PRP) to placebo (imitation) injection in adults with Achilles tendon pain.

Principal Investigator: Mr Michael Hennessy

Research Nurses: Mandy Edwards

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Study Title - Investigating Molecular & Cellular Biology Mechanisms in Articular Cartilage

Principal Investigator: Mr Richard Parkinson

Research Nurses: N/A

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Parkinson’s Disease Research

PROBAND - Parkinson's Repository of Biosamples and Network Datasets

Principal Investigator:  Dr Mary O’Neill

Research Nurse:  Andrea Young

Paediatric Research

Study Title - ADDRESS 2 - An incident and high risk type 1 diabetes research cohort After Diagnosis Diabetes Research Support System

Principal Investigator:  Dr C De Silva

Research Nurses: Lucy Lewis and Sharon Hughes

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Study Title - Baby Oscar - Outcome After Selective Early Treatment for Closure of Patent Ductus Arteriosus in Preterm Babies

Principal Investigator: Dr Anand Kamalanathan

Research Nurses: Lucy Lewis and Sharon Hughes

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Study Title - CF Start - The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF.

Principal Investigator: Dr David Lacy

Research Nurses: Lucy Lewis and Sharon Hughes

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Study Title - FADES - Feeding and Autoimmunity in Down's syndrome Evaluation Study

No Local Investigator:  This trust is a Participant Identification Centre only

Research Nurses: Lucy Lewis and Sharon Hughes

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Study Title - OPTI-PREM – Optimising Neonatal Service provision for preterm babies born between 27 and 31 weeks of gestation in England, using national data, qualitative research and economic analysis    

Principal Investigator: Dr Anand Kamalanathan

Research Nurses: Lucy Lewis and Sharon Hughes

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Study TitlePiC – Petechiae in Children (PIC) Study: defining a clinical decision rule for the management of fever and non-blanching rashes in children including the role of point of care testing for procalcitonin & neisseria meningitidis DNA

Principal Investigator: Dr Santosh Keshavamurthy

Research Nurses: Lucy Lewis and Sharon Hughes

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Study TitleRAACENO – Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy - a randomised trial

Principal Investigator: Dr Sudeshna Bhowmik

Research Nurses: Lucy Lewis and Sharon Hughes

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Study TitleScience - Surgery or Cast for Injuries of the epicondyle in children’s elbows

Principal Investigator:  Mr Simon Robinson

Research Nurses: Lucy Lewis and Sharon Hughes

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Study Title - UK Childhood ITP Registry

Principal Investigator:  Dr Oliver Rackham

Research Nurses: Lucy Lewis and Sharon Hughes

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Renal Research

Study Title - PURE - The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: The Percutaneous nephrolithotomy, flexible Ureterorenoscopy and Extracorporeal shockwave lithotripsy for lower pole kidney stones Randomised Controlled Trial 

Principal Investigator: Mr Snahel Patel

Research Nurse:  Reni Jacob and Cathy Jones

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Study Title - RADAR - National Registry of Rare Kidney Diseases 

Principal Investigator: Dr Thomas Ledson

Research Nurse: Reni Jacob and Cathy Jones

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Study TitleSIMPLIFIED  - Survival Improvement with Cholecalciferol in Patients on Dialysis

Principal Investigator: Dr Thomas Ledson

Research Nurse:  Reni Jacob and Cathy Jones

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Study Title - The UK Calciphylaxis Study 

Principal Investigator: Dr Noshaba Naz

Research Nurse: Reni Jacob and Cathy Jones

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Reproductive Health Research

Study Title - ALIFE 2 - Anticoagulants for Living FoEtuses in women with recurrent miscarriage and inherited thrombophilia

Principal Investigator: Mr Michael Ellard

Research Midwife: Julie Grindey

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Study Title - C-STICH - The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH) Trial: A Randomised Controlled Trial of monofilament versus braided sutures for insufficient cervix.

Principal Investigator: Miss Rajeshwari Myagerimath

Research Midwife: Julie Grindey

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Study Title - FUTURE - Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study); a superiority randomised clinical trial to evaluate the effectiveness and cost effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms.

Principal Investigator: Mr Mark Doyle

Research Midwife: Julie Grindey

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Study Title – SUPPORT - Stitch, Progesterone or Pessary: a Randomised Trial

Principal Investigator: Ms Rajeshwari Myagerimath

Research Midwife: Julie Grindey

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Study Title – TTTS – Multiple Pregnancy Registry

Principal Investigator: Ms Rajeshwari Myagerimath

Research Midwife: Julie Grindey

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Respiratory Research

ASAP - Early low dose steroids for adults admitted to hospital with influenza-like illness during a pandemic: a randomised placebo controlled trial

Principal Investigator: Dr A Wright 

Research Nurse: Liz Bailey

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EMBARC - The European Bronchiectasis Registry

Principal Investigator: Dr N Stevenson

Research Nurse: Liz Bailey

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Study Title – BICS - A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of COPD

Principal Investigator:  Dr David Tarpey

Research Nurse: Liz Bailey

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Rheumatology Research

Study Title  - BSRBR Register - Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis

Principal Investigator: N/A

Research Nurse: Julie McEntee 

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Study Title - CREDO 4 – A Multi-centre, Open-Label, Phase III Study of the Efficacy and Safety of Olokizumab in Subjects with Moderately to Severely Active Rheumatoid Arthritis.

Principal Investigator: Dr Emmanuel George

Research Nurse: Julie McEntee

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Study Title - GCA Consortium - Clinical and immunogenetic characterization of Giant Cell Arteritis (GCA) and polymyalgia rheumatica (PMR)

Principal Investigator: Dr Emmanuel George

Research Nurse: Julie McEntee

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Study Title - Inflammatory Signaling Pathways

Principal Investigator: Dr Emmanuel George

Research Nurse: Julie McEntee 

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Study Title:  British Society for Rheumatology Psoriatic Arthritis Register

Principal Investigator: Dr Emmanuel George

Research Nurse: Julie McEntee

Stroke Research

Study TitleELAN - Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillation: an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial

Principal Investigator: Dr Brian Menezes

Research Nurse: Venetia Johnson 

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Study Title - Optimizing prediction of stroke outcome using brain imaging machine- e-learning.

Principal Investigator: Dr Ruth Davies

Research Nurse: Venetia Johnson 

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Study Title - Patient and Carer Experience of Post-Stroke Motor Apraxia

Principal Investigator: Dr Ruth Davies

Research Nurse: Venetia Johnson 

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Study Title - PRECIOUS - Prevention of complications to Improve outcome in elderly patients with acute stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment.

Principal Investigator: Dr Ruth Davies

Research Nurse: Venetia Johnson 

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Study TitleRV4AD - Rates, Risks and Routes to Reduce Vascular Dementia

Principal Investigator: Dr Ruth Davies

Research Nurse: Venetia Johnson 

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Study TitleSo-START - Start or stop anticoagulants randomised trial after spontaneous intracranial haemorrhage

Principal Investigator: Dr Brian Menezes

Research Nurse: Venetia Johnson 

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Study TitleTWIST - randomised-controlled trial of thrombolytic treatment with tenecteplase for acute ischaemic stroke upon awakening

Principal Investigator: Dr Ruth Davies

Research Nurse: Venetia Johnson 

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Surgery Research

Study TitleROSSINI 2 – A Phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor) multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of three in-theatre interventions, alone or in combination, to reduce SSI rates in patients undergoing abdominal surgery

Principal Investigator: Mr Liviu Titu

Research Nurse: Anne Reddington

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Vascular Research

Study Title - Tomographic ultrasound for the detection of complications following surgically created arterio-venous fistulae for haemodialysis

Principal Investigator: Mr Ramasubramanyan Chandrasekar

Research Nurse: N/A

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Colorectal

Study Title - The CIPHER Study - UK Cohort study to investigate the prevention of parastomal Hernia

Principal Investigator: Mr Ciaran Walsh

Research Nurse: Helyn Evans 

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Study Title - PITSTOP – PIlonidal sinus treatment: studying the options

Principal Investigator: Mr Jeremy Wilson

Research Nurse: Anne Reddington

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Study TitlePPAC2 – The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial

Principal Investigator:  Mr Liviu Titu

Research Nurse: Anne Reddington

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Microbiology

Study Title – ARK – Antibiotic Review Kit for Hospitals

Principal Investigator:   Dr David Harvey

Research Nurse: N/A

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