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Research Department

Our NHS Trust actively supports and encourages research. We currently have over 60 research studies open and during 2016/17 over 700 patients participated in a wide variety of studies. 

Many of our doctors engage in research and they are supported by a team of 12 research nurses, a research midwife and the administrative staff based within the Research Department.

 

Information for Patients and Carers

Research is vital in order to provide evidence to improve treatment for patients within our care. If your doctor is in agreement, you may be invited to participate whilst you are a patient at one of our hospitals.  Detailed information will be provided to enable you to make an informed decision about deciding to participate.

You will be provided with the following:

  • a full explanation of the study by your doctor or nurse
  • a full explanation of potential benefits (or risks) of participating in the study
  • a copy of the Patient Information Sheet
  • sufficient time to allow you to make an informed decision to participate in the study, including time to talk about the study with family or friends
  • sufficient time to allow you to ask any additional questions that you may have
  • a Patient Consent Form to sign to confirm that you understand the study and wish to participate
  • an understanding that you can withdraw, at any time, from the study without compromising your care.

All research within our Trust will have received the appropriate regulatory approvals prior to the research starting.

Types of research available

We ask suitable patients to participate in different types of research within the trust. The types of research can vary from a clinical trial (to test a new drug or to test a licensed drug in a different way), to asking patients to complete a simple questionnaire regarding their quality of life.  We undertake research that is sponsored by national charities, academic institutions or pharmaceutical companies.

During 2016/17 we recruited 741 participants to NIHR research studies.

Specialities involved in research within the trust

The following specialities are currently involved in research within the trust:

  • Cancer
  • Cardiovascular
  • Critical Care
  • Dermatology
  • Elderly Medicine
  • Haematology
  • Injuries & Emergencies
  • Neonates
  • Parkinson's Disease
  • Paediatrics
  • Reproductive Health
  • Respiratory
  • Rheumatology
  • Stroke
  • Surgery
  • Urology 

(This list changes from time to time due to the availability of suitable studies for our patients)

Research on healthy volunteers

This hospital does not routinely undertake research on healthy volunteers. However, occasionally we may participate in a research project which invites patients’ relatives (healthy volunteers), to take part. For example, the daughter of a patient with breast cancer may be offered the opportunity to be screened to see if she has a ‘familial gene’ that may predispose her to the condition. Additionally, patients’ carers and relatives may be asked about their experience whilst visiting the hospital.

Patient and Public Involvement (PPI)

If you are a patient, carer, or a member of public with an interest, you can help research by becoming more actively involved and having a say.  The NHS National Institute for Health Research offers further details about research. Click here to be taken to their website.

Research terminology

A list of commonly used research abbreviations can be seen by clicking here.

 

Meet the team

The Research Department forms part of the Quality and Safety Department within the Corporate Division of the Trust. The Research Lead is Dr Melanie Maxwell, Associate Medical Director.

The Department also includes (with internal phone number)

Paula Brassey, Research Manager - 8471

Fiona Brailsford, Research Coordinator - 8471

Joanne Mullen, Research Data Coordinator - 2476

Angela Dodd, Stroke Research Nurse - 2958

Cathy Jones, A&E and Critical Care Research Nurse - 2717

Helyn Evans, Surgery Research Nurse - 2120

Jessie Huang, Haematology Research Nurse - 2476

Julie Grindey, Research Midwife - 8913

Joan Walker, Dermatology Research Nurse - 4221

Liz Bailey, Senior Research Nurse - 7138

Lucy Lewis, Paediatric Research Nurse - 2520

Reni Jacob, A&E and Critical Care Research Nurse - 2717

Sarah Lacy, Haematology Research Nurse - 2310

Sarah Peers, Rheumatology Research Nurse - 2310

Sharon Hughes, Paediatric Research Nurse - 2520

Tony Lake, Rheumatology Research Nurse - 2310


Main Switchboard Number: 0151 678 5111

Commercial Research

We participate in a wide variety of commercial research. Many of our commercial studies have been adopted onto the National Institute for Health Research (NIHR) portfolio but we do however undertake commercial studies that have not been adopted onto the NIHR portfolio.  We are always interested in working with new commercial partners.  If you wish to see a copy of our NIHR R&D Capability Statement please contact the Research Manager.

The Trust encourages the use of model Clinical Trial Agreements for research and the use of the NIHR Industry Costing Template.

If you wish to find out further information please contact:

Paula Brassey, Research Manager

Telephone: 0151 678 5111 ex 8471

Email:  Paula.Brassey@nhs.net

NIHR Performance in Initiating and Delivering Clinical Research

The Government wishes to see a dramatic and sustained improvement in the performance of all providers of NHS services in initiating and delivering clinical research. The aim is to increase the number of patients who have the opportunity to participate in research and to enhance the nation’s attractiveness as a host for research. 

Since October 2014 the Trust has produced quarterly returns to the National Institute of Health Research (NIHR) on its performance in two key areas:

  • Initiating clinical research
  • Delivering commercial contract clinical research to time and target

Copies of reports are within the tabs below.  More information about this can be found via this link or by contacting Paula Brassey, Research Manager.  

Oct 2014

Please click on the links below for a copy of information for October 2014:

 

 

January 2015

Please click on the links below for a copy of information for January 2015:

Performance in initiating clinical research, January 2015

Performance in delivering clinical research, January 2015

April 2015

Please click on the links below for a copy of the information upload April 2015.

Performance in Initiating Clinical Research April 2015

Performance in Delivering Clinincal Research April 2015

July 2015

Please click on the links below for a copy of the information for July 2015:

 

Performance in Initiating Clinical Research, July 2015

Performance in Delivering Clincal Research, July 2015

October 2015

Please click on the links below for a copy of the information for Oct 2015:

 

Performance in Initiating Clinical Research Oct 2015

Performance in Delivering Clinical Research Oct 2015

January 2016

Please click on the links below for a copy of the information for Jan 2016

 

Performance in Initiating Clinical Research

Performance in Delivering Clinical Research 

 

 

April 2016

Click on links below for information relating to April 2016:

Performance in Initiating Clinical Research

Performance in Delivering Clinical Research

July 2016

Please click on the links below for a copy of the information for July 2016

 

Performance in initiating clinical research

Perfermonce in delivering clinical research

October 2016

Please click on the links below for a copy of information for October 2016:

 

Performance in initiating research Oct 2016

Performance in delivering research Oct 2016

January 2017

Please click on the links below for a copy of information for January 2017:

Performance in Initiating Clinical Research January 2017

Performance in Delivering Clinical Research January 2017

List of open NIHR research studies

Below is a list of studies open at this Trust that have been adopted onto the National Institute for Health Research (NIHR) Portfolio.

Please speak to your doctor or nurse about the research opportunites that may available to you.

Cancer Research

Study Title

ADD-ASPIRIN - A phase III double-blind placebo-controlled randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours

Principal Investigator: Mr Liviu Titu

Sub Investigators: Mr Nigel Parr and Mr Raman Vinayagam

Research Nurses: Liz Bailey, Helyn Evans & Andrea Young

 

BOWEL CANCER

Study Title

PRESENT - Predisposition to serrated neoplasia and tumours

 

COLON CANCER

Study Title

FOXTROT - Fluoropyrimidine, Oxaliplatin & Targeted Receptor pre-Operative Therapy for colon cancer. A randomised trial assessing whether preoperative chemotherapy and/or an anti-EGFR monoclonal antibody improves outcome in high-risk operable colon cancer.

This study is open in conjunction with Clatterbridge Cancer Centre.

Principal Investigator: Dr Nicholas Day

 

 

PROSTATE CANCER

Study Title

UK Genetic Prostate Cancer Study (UKGPCS)

Principal Investigator: Dr Nigel Parr

Research Nurse: Andrea Young

 

RECTAL CANCER

Study Title

ARISTOTLE - A trial comparing standard versus novel CRT as pre-operative treatment for MRI defined locally advanced rectal cancer

This study is open in conjunction with Clatterbridge Cancer Centre.

Principal Investigator:  Mr Liviu Titu

 

 

RENAL CANCER

Study Title

A-PREDICT - A Study of Axitinib in Patients with Metastatic Renal Cell Cancer Unsuitable for Nephrectomy

This study is open in conjunction with Clatterbridge Cancer Centre.

Principal Investigator:  Dr Richard Griffiths

 

 

UROLOGICAL CANCER

Study Title

HYBRID - A multicentre randomised phase II study of HYpofractionated Bladder Radiotherapy with or without Image guided aDaptive planning.

This study is open in conjunction with Clatterbridge Cancer Centre; this Trust is a Participant Identification Centre.

 

 

 

 

 

Cardiovascular Research

Study Title

FOURIER - A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease.

Study recently closed; patients are in follow-up.

Principal Investigator Dr P Saravanan

Research Nurse Liz Bailey

 

Study Title

LIVE LIFE - Older heart failure patients Initiated on iVabradinE in UK quality of liFE

Study recently closed; currently patients are in follow-up.

Principal Investigator Dr P Saravanan

Research Nurse Liz Bailey

 

Study Title

COMMADNER HF - A Randomised, Double-Blind, Event-Driven, Multicentre Study Comparing the Efficacy and Safety of Oral Rivaroxaban with Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects with Chronic Heart Failure and Significant Coronary Artery Disease Following a Hospitalisation for Exacerbation of Heart Failure

Principal Investigator Dr P Saravanan

Research Nurse Liz Bailey

 

Critical Care Research

Study Title

PAINTED - Pandemic Influenza Triage in the Emergency Department

Principal Investigator Dr Andrea Wooten

Research Nurse Reni Jacob & Cathy Jones

 

Study Title

ARREST - Adjunctive Rifampicin to Reduce Early mortality from Staphylococcus aureus bacteraemia: a randomised controlled trial

Principal Investigator Dr David Harvey

Research Nurse Reni Jacob & Cathy Jones

 

Study Title

CRASH 3 - Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: An International, Randomised, Double Blind, Placebo Controlled Trial

Principal Investigator Dr Andrea Wootten

Research Nurse Reni Jacob  & Cathy Jones

 

Study Title

BEST - The Bedside Evaluation of Sensitive Troponin study

Principal Investigator Dr Andrea Wootten

Research Nurse Reni Jacob & Cathy Jones

 

Dementia Research

Study Title

Proband - Parkinson's Repository of Biosamples and Network Datasets

Principal Investigator:   Dr Mary O'Neill

Research Nurse:  Andrea Young

 

Study Title

Parkinson’s Pain Study

Principal Investigator:   Dr Mary O'Neill

Research Nurse:  Andrea Young

 

Study Title

Parkinson's disease DNA Bank 

Principal Investigator:   Dr Mary O'Neill

Research Nurse:  Andrea Young

 

Dermatology Research

Study Title

BADBIR -British Association of Dermatologists Biologic Interventions Register

Principal Investigator: Dr Stephen white

Research Nurse:  Joan Walker

 

 

Haematology Research

Study Title

RIALTO - An Investigation of Alternative Ofatumumab containing regimens in less fit patients with CLL

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang & Sarah Lacy

 

Study Title

PACIFICO - Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for Older patients

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang & Sarah Lacy

 

Study Title

ReMODL B - An evaluation of molecular guided therapy for diffuse large B-cell lymphoma with Bortezomib

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang

 

Study Title

Myeloma Xl - Comparisons in myeloma patients of all ages of thalidomide, lenalidomide and bortezomib combinations and maintenance lenalidomide

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang & Sarah Lacy

 

Study Title

AML L1 - Leukaemia Lymphoma Research and NCRI Working Group Programme 

Principal Investigator:  Dr David Galvani

Research Nurse:  Jessie Huang & Sarah Lacy

 

Study Title

MAJIC - A study of best available therapy versus JAK Inhibition in patients with high risk Polycythaemia Vera or Essential Thrombocythaemia 

Principal Investigator:  Dr David Galvani

Research Nurse:  Jessie Huang

 

Study Title

INCITE - Intracranial Haemorrhage in Thrombocytopenic Haematology Patients

Research Nurse:  Jessie Huang & Sarah Lacy

 

Study Title

UKALL 14 - A  trial for adults with newly diagnosed acute lymphoblastic leukaemia

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang

 

Study Title

SPIRIT 2 - A comparison of imatinib (STI571, Glivec/Gleevec) 400mg daily versus dasatinib (Sprycel) 100mg daily in patients with newly-diagnosed chronic phase chronic myeloid leukaemia

Principal Investigator:  Dr Ranjit Dasgupta

Research Nurse:  Jessie Huang & Sarah Lacy

 

Study Title

UK ALL 60+  - A Phase 2 study for older adults with Acute Lymphoblastic Leukaemia 

Principal Investigator:  Dr Barbara Hammer

Research Nurses:  Jessie Huang & Sarah Lacy

 

Study Title

MRC PT1 - A Randomised Trial to compare Aspirin versus Hydroxyurea/ Aspirin in ‘Intermediate Risk’ Primary Thrombocythaemia and Aspirin only with Observation In ‘Low Risk’ Primary Thrombocythaemia 

Principal Investigator:  Dr Barbara Hammer

Research Nurses:  Jessie Huang & Sarah Lacy

 

Study Title

AML 19 - A national cancer research institute acute myeloid leukaemia (AML) working group pilot trial to establish the feasibility of combining tyrosine kinase inhibitor, ponatinib with chemotherapy in patients with AMLwith a flt3 mutation.

Principal Investigator:   Dr David Galvani

Research Nurses: Jessie Huang & Sarah Lacy

 

Study Title

AML 18 - A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome

Principal Investigator:   Dr Ranjit Dasgupta

Research Nurses: Jessie Huang & Sarah Lacy

 

Study Title

MCL Biobank - Establishing a Biobank and Database as a National Resource for Characterising Indolent and Aggressive forms of Mantle Cell Lymphoma, an Observational Study.

Principal Investigator:   Dr Barbara Hammer

Research Nurses: Jessie Huang & Sarah Lacy

 

Microbiology Research

Study Title

ENCEPH UK - A Prospective Cohort Study of Clinical Predictors, Disease Mechanisms, Costs and Outcomes of Encephalitis in the UK

Principal Investigator:  Dr Kavya Mohandas

Research Nurse  Reni Jacob

 

Study Title

Meningitis UK (previously Meningitis NW) - Epidemiology and outcomes in meningitis - A prospective, observational, cohort study

Principal Investigator:  Dr Kavya Mohandas

Research Nurse Reni Jacob

 

 

Paediatric Research

Study Title

ICISS - The International Collaborative Infantile Spasms Study

Principal Investigator:  Dr Adrian Hughes

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

PiPS - Early administration to preterm infants of the probiotic Bifidobacterium breve BBG to prevent sepsis and Necrotising Enterocolitis

Principal Investigator:  Dr Adrian Hughes

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

ADDRESS 2 - An incident and high risk type 1 diabetes research cohort After Diagnosis Diabetes Research Support System

Principal Investigator:  Dr Jude Joseph

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

PREDNOS ll - Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome

Principal Investigator:  Dr Elizabeth Breen

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

SANAD ll - a comparison of Standard And New Antiepileptic Drugs

Principal Investigator:  Dr Adrian Hughes

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

UK Chimes - UK Childhood Meningitis and Encephalitis Cohort Study

Principal Investigator:  Dr James Pauling

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

UK Childhood ITP Registry

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

SiFT - Speed of Increasing milk Feeds Trial 

Principal Investigator:  Dr Adrian Hughes

Research Nurses: Lucy Lewis and Sharon Hughes

No longer recruiting to this study; patients are in follow-up.

 

Study Title

HUMOX - A pilot study to assess whether humidified oxygen is more effective that standard oxygen therapy in treating children with acute severe asthma

Principal Investigator:  Dr David Lacy

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

PLANET 2 - A randomised Phase II study of carboplatin with or without the addition of the ETAR inhibitor ZD4054 as treatment for patients with metastatic breast cancer

Principal Investigator:  Dr Oliver Rackham

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

FADES - Feeding and Autoimmunity in Down's syndrome Evaluation Study

No Local Investigator:  this trust is a Participant Identification Centre

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

ARCHIE - The early use of Antibiotics for at Risk CHildren with InfluEnza in primary care: a double-blind randomised placebo-controlled trial

Principal Investigator: Dr E Breen

Research Nurses: Lucy Lewis and Sharon Hughes

 

Study Title

PUMA - PUMA Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance. A prospective, mixed methods, before and after study identifying the evidence base for the core components of an effective PEWS and the development of an implementation package for implementation and use in the UK

Principal Investigator:  Dr David Lacy

 

Renal Research

Study Title

BiCARB - Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial.

Princiapal Investigator: Dr Alex Crowe

Research Nurse: Andrea Young

 

Study Title

PiVOTAL - UK Multicentre Open-label Randomised Controlled Trial Of IV Iron Therapy In Incident Haemodialysis Patients.

Princiapal Investigator: Dr Thomas Ledson

Research Nurse: Lynn Fisher

This study is now closed.

 

Reproductive Health Research

Study Title

TABLET - The Efficacy and Mechanism of Levothyroxine Treatment on Pregnancy and Neonatal Outcomes in Women with Thyroid Antibodies

Principal Investigator: Mrs Stella Mwenechanya

Research Midwife: Julie Grindey

 

Study Title

TABLET – Prevalence Study (linked to the above study)

Principal Investigator: Mrs Stella Mwenechanya

Research Midwife: Julie Grindey

 

Study Title

VUE - Two trials of surgical options for upper compartment (vauilt or uterine) pelvic organ prolapse

Principal Investigator: Mr Jeremy Weetch

Research Midwife: Julie Grindey

 

Study Title

NBSP - The provision of antenatal information for the NHS Newborn Bloodspot Screening Programme 

Research Midwife: Julie Grindey

 

Study Title

DAPPA - Spot protein creatinine ratio (SPCr) and spot albumin creatinine ratio (SACr) in the assessment of pre-eclampsia: A diagnostic accuracy study with decision analytic model based economic evaluation and acceptability analysis

Principal Investigator: Mrs S Mwenechanya

Research Midwife: Julie Grindey

 

Study Title

MiNESS - The Midlands and North of England Stillbirth Study MiNESS

Principal Investigator: Mrs S Mwenechanya

Research Midwife: Julie Grindey

 

Study Title

Health - A multicentre randomised controlled trial comparing laparoscopic supra-cervical hysterectomy with second generation endometrial ablation for the treatment of heavy menstrual bleeding 

Principal Investigator: Mr Jeremy Weetch

Research Midwife: Julie Grindey

 

Study Title

SIMS - Adjustable Anchored SingleIncision MiniSlings Versus Standard TensionFree MidUrethral Slings in the Surgical Management Of Female Stress Urinary Incontinence; A Pragmatic Multicentre Non–Inferiority Randomised Controlled Trial

Principal Investigator: Mr M Doyle

Research Midwife: Julie Grindey

 

Respiratory Research

Study Title

ASAP - Early low dose steroids for adults admitted to hospital with influenza-like illness during a pandemic: a randomised placebo controlled trial

Principal Investigator: Dr A Wright 

Research Nurse: Liz Bailey

 

Study Title

PASIC - Pharmacogenetics of Adrenal Suppression with Inhaled corticosteroids in adults with Chronic Obstructive Pulmonary Disease

Principal Investigator: Dr N Stevenson

Research Nurse: Liz Bailey

 

Study Title

FAST FOUR FOLD Study - The clinical and costeffectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations; a pragmatic, randomised, normal carecontrolled, clinical trial.

Principal Investigator: Dr N Stevenson

Research Nurse: Liz Bailey

 

Study Title

EMBARC - The European Bronchiectasis Registry

Principal Investigator: Dr N Stevenson

Research Nurse: Liz Bailey

Rheumatology Research

Study Title

The Genetics of Ankylosing Spondylitis

Principal Investigator: Dr Emmanuel George

Research Nurse: Tony Lake and Sarah Peers

 

Study Title

A Global Comparative Observational Study in Rheumatoid Arthritis Patients who are treated with a TNF Inhibitor or Tocilizumab as the first Biologic Therapy

Principal Investigator: Dr Emmanuel George

Research Nurse: Tony Lake and Sarah Peers

 

Study Title

Rapsody - A Double Blind,Randomized, ParallelGroup, ActiveControl Study to Compare the Efficacy and Safety of CHS0214 Versus Enbrel® in Subjects With Rheumatoid Arthritis and Inadequate Response to Treatment With Methotrexate

Principal Investigator: Dr Emmanuel George

Research Nurse: Tony Lake and Sarah Peers

 

Study Title

GCA Consortium - Clinical and immunogenetic characterization of Giant Cell Arteritis (GCA) and polymyalgia rheumatica (PMR)

Principal Investigator: Dr Emmanuel George

Research Nurse: Tony Lake and Sarah Peers

 

Stroke Research

Study Title

TARDIS - Safety and efficacy of intensive versus guideline antiplatelet therapy in high risk patients with recent ischaemic stroke or transient ischaemic attack

Principal Investigator: Dr Ruth Davies

Research Nurse: Angela Dodd

 

Study Title

RESTART - REstart or Stop Antithrombotics

Principal Investigator: Dr Ruth Davies

Research Nurse: Angela Dodd

 

Study Title

TICH 2 - Tranexamic acid for IntraCerebral Haemorrhage 

Principal Investigator: Dr Ruth Davies

Research Nurse: Angela Dodd

 

Study Title

GLORIA - Global Registry on Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial Fibrillation 

Principal Investigator: Dr Ruth Davies

Research Nurse: Angela Dodd

 

Study Title

ADOPTS - Accelerating Delivery Of Psychological Therapies after Stroke 

Principal Investigator: Dr Ruth Davies

Research Nurse: Angela Dodd

 

Surgery Research

Study Title

FIAT -  The Fistula-In-Ano Trial comparing Surgisis® anal fistula plug versus surgeon’s preference for transsphincteric fistula-in-ano 

Principal Investigator: Mr Liviu Titu

Research Nurse: Helyn Evans

 

 

 

Urology Studies

Study Title

OPEN - Clarifying the management of men with recurrent urethral stricture: A pragmatic multicentre randomised superiority trial of open urethroplasty versus endoscopic urethrotomy

Trust Lead:  Mr Paul Kutarski

This Trust is a Participant Identification Centre for this study.

 

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